RIG - Nanomedicine & Drug Delivery Research Group (NDDRG)

1. 20 years’ experience in the synthesis and characterization of nanoparticles/nano-drug-delivery systems, nano-formulations and in vitro/in vivo assessments of nano-therapeutics/delivery systems
2. Unique technology in

   - Renal-targeted drug delivery system
   - stimulus (ultrasound/light)-guided nano-drug targeting/activation 
   - radiotelemetry-based nanotoxicity assessment  
   - synthesis of low-dimensional nanotherapeutics
   - biosensor-based rapid drug-screening
   - Endogenous encapsulation of biologics into exosomes

3. Well-established research networking with the internationally renowned researchers/research groups

National 

1. Dr. Ng Shiow Fern | Faculty of Pharmacy, Universiti Kebangsaan Malaysia
2. Dr. Saiful Effendi Syafruddin | UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia
3. Dr. Fu Ju Yen | Malaysian Palm Oil Board
4. Dr. Low May Lee | Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Malaysia
5. Dr. Ahmad Hazri Abd Rashid | SIRIM, Malaysia
6. Mr. Mohd Helme bin Mohd Helan | National Nanotchnology Center (NNC), Ministry of Energy, Science, Technology, Environment & Climate Change (MESTECC), Malaysia

International 

1. Prof. Dr. Maria J. Vicent | Polymer Therapeutics Laboratory, Centro de Investigación Príncipe Felipe, Spain
2. Prof. Dr. Toyoko Imae | Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taiwan
3. Prof. Dr. Dr. Nina Japundžić-Žigon | Institute of Pharmacology, Clinical Pharmacology and Toxicology, University of Belgrade. Serbia
4. Prof. Dr. Kevin Burgess | Department of Chemistry, Texas A&M University. USA
5. Prof. Dr. David Murphy | School of Clinical Sciences, University of Bristol, UK
6. Prof. Dr. Edward James Johns | Physiology Department, University College Cork, Ireland
7. Prof. Dr. Chia-Ching Chang | Department of Biological Science and Technology,National Chiao Tung University, Taiwan
8. Prof. Dr. Dar-Bin Shieh | School of Dentistry, National Cheng Kung University, Taiwan
9. Prof. Dr. Steve Roffler | Institute of Biomedical Sciences, Academia Sinica. Taiwan
10. Prof. Dr. Shinru Shih | Research Center for Emerging Viral Infections, Chang Gung University, Taiwan
11. Asst. Prof. Dr. Fabienne Dumoulin | Chemistry Department, Gebze Technical University. Turkey
12. Prof. Khuloud Al-Jamal | Institute of Pharmaceutical Science, King’s College London, UK

Completed:

1. Nano-stealthing the STAT3-blocker for improved anti-metastatic activity: mechanistic and pharmacological studies, FRGS 2017
2. Targeted delivery of cancer chemotherapy pro-drugs, MOHE-HIR 2013
3. Targeted delivery of anti-neoplastic photoactive compounds and peptides, MOHE-HIR 2011

Ongoing: 

1. Fundamental Investigation on the Nanocarrier-assisted Rapid Drug Urothelial Mucopenetration and Ultrasound-regulated Tumour-selective Bladder Drug Delivery to Improve Intravesical Bladder Cancer Therapy, FRGS 2022
2. Evaluating directed encapsulation of CRISPR/Cas9 as self-assembled ribonucleoprotein (RNP) complex into exosomes for CD73 ablation as locally administered lung cancer immunotherapy, FRGS 2022
3. Development of industrial prototype of polymeric targeted and non-targeted nanoparticle formulation for the treatment of cancer: preclinical and technical evaluation, PRGS 2021
4. Discovery of Novel Exosome-based Biomarkers for Machine-learning Assisted Biosensing in Lung Cancer Early Detection, IIRG 2021
5. Targeting Tropomyosin Receptor Kinase C Expressing Cancer Cells through Synthetic Ligand Conjugate and Cyclophosphamide for Immunotherapy, FRGS 2020
6. Bacterial membrane targeting agent - ruthenium/rhenium-based photosensitizer conjugates as novel effective therapeutics against multi-drug resistant bacteria: feasibility and synergistic mechanism studies, FRGS 2020
7. Design And Development of Antimicrobial Molecules/anti-virulence Agents for Suppression of Biofilm Formation of Staphylococcus Aureus, IIRG 2019
8. Stimuli responsive double-stealth–pre-targeting strategy to improve targeted anticancer nano-drug delivery to deep tumour tissues: Mechanism and pharmacology, FRGS 2019

Expertise/ collaboration:

1. Renal-targeted drug delivery
2. Stimulus-guided nano-drug targeting/activation
3. Nanotoxicity assessment
4. Synthesis of low-dimensional nanotherapeutics
5. Biosensor-based rapid drug-screening/medical diagnosis
6. Exosome-based Nanobiologics
7. Other nano-drug-delivery/ nanotherapeutics applications

Assoc. Prof. Dr. Kiew Lik Voon
Department of Pharmacology
https://umexpert.um.edu.my/lvkiew.html  
03-79675720
lvkiew@um.edu.my