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Research Interest Group
(Name of Group & Brief Description)

Nanomedicine & Drug Delivery Research Group (NDDRG)

NRG focuses on the in the development, formulation and pharmacokinetic/dynamic assessments of nano-sized complexes and nano-constructs for anticancer/organ-selective drug delivery and therapy, and stimulus (ultrasound/light)-guided nano-drug targeting/activation.

NRG also venture into exosome-based nanobiologics research, bio-sensing for medical diagnosis and rapid drug-screening purposes, and cardiovascular nanotoxiciy assessment via radio-telemetry and electron microscopy techniques.

Current Convenors / Head Name: Assoc. Prof. Dr. Kiew Lik Voon
Department: Pharmacology
Link to UMExpert: UMExpert: https://umexpert.um.edu.my/lvkiew.html 
RIG Members
1. Name: Assoc. Prof. Dr. Kiew Lik Voon
Department: Pharmacology
Expertise/research interest: anticancer nanotherapeutics; organ/tumour-selective drug delivery; stimulus (ultrasound/light)-guided nano-drug targeting/activation; nanotoxicity assessment; biosensor-based rapid drug-screening
Link to UMExpert: https://umexpert.um.edu.my/lvkiew.html
2. Name: Dr. Muhammad Farid Nazer Bin Muhammad Faruqu
Department: Pharmacology
Expertise/research interest: Exosome and nano-drug delivery; Nanobiologics
Link to UMExpert: https://umexpert.um.edu.my/faridnazer.html
3. Name: Dr. Leo Bey Fen
Department: Molecular Medicine
Expertise/research interest: Bio-sensing for medical diagnosis, nanotoxicity assessment
Link to UMExpert: https://umexpert.um.edu.my/beyfenleo.html
4. Name: Prof. Dr. Zamri Chik
Department: Pharmacology
Expertise/research interest: Pharmacokinetics, in vitro and in vivo evaluation of nanoformulations and topical/transdermal drug delivery system
Link to UMExpert: https://umexpert.um.edu.my/zamrichik.html
5. Name: Associate Prof. Dr. Teo Yin Yin
Department: Chemistry (Faculty of Science)
Expertise/research interest: Colloid nanoparticle formulation
Link to UMExpert: https://umexpert.um.edu.my/yinyinteo.html
6. Name: Prof. Dr. Misni Bin Misran
Department: Chemistry (Faculty of Science)
Expertise/research interest: Colloid nanoparticle synthesis & characterization
Link to UMExpert: https://umexpert.um.edu.my/misni.html
7. Name: Prof. Dr. Chung Lip Yong
Department: Pharmaceutical Chemistry (Faculty of Pharmacy)
Expertise/research interest: Nanocarrier synthesis & characterization
Link to UMExpert: https://umexpert.um.edu.my/chungly.html
8. Name: Dr. Heh Choon Han
Department: Pharmaceutical Chemistry (Faculty of Pharmacy)
Expertise/research interest: molecular modelling of nanoparticle-nanoparticle/nanoparticle-drug interactions
Link to UMExpert: https://umexpert.um.edu.my/silverbot.html
9. Name: Dr. Chin Sek Peng
Department: Pharmaceutical Chemistry (Faculty of Pharmacy)
Expertise/research interest: molecular modelling of nanoparticle-nanoparticle/nanoparticle-drug interactions
Link to UMExpert: https://umexpert.um.edu.my/spchin.html
10. Name: Assoc. Prof. Dr. Goh Boon Tong
Department: Physics (Faculty of Science)
Expertise/research interest: metallic nanomaterial synthesis/characterization
Link to UMExpert: https://umexpert.um.edu.my/gohbt.html
11. Name: Dr. Chee Chin Fei
Department: Nanotechnology Catalysis Research Centre
Expertise/research interest: biomaterial preparation and fabrication
Link to UMExpert: https://umexpert.um.edu.my/cheechinfei.html
12. Name: Dr. Nam Hui Yin
Department: Nanotechnology Catalysis Research Centre
Expertise/research interest: biomaterials for tissue repair
Link to UMExpert: https://umexpert.um.edu.my/namhuiyin26.html

Group Strength
  1. 20 years’ experience in the synthesis and characterization of nanoparticles/nano-drug-delivery systems, nano-formulations and in vitro/in vivo assessments of nano-therapeutics/delivery systems
  2. Unique technology in

    - Renal-targeted drug delivery system
    - stimulus (ultrasound/light)-guided nano-drug targeting/activation 
    - radiotelemetry-based nanotoxicity assessment  
    - synthesis of low-dimensional nanotherapeutics
    - biosensor-based rapid drug-screening
    - Endogenous encapsulation of biologics into exosomes

  3. Well-established research networking with the internationally renowned researchers/research groups


  1. Dr. Ng Shiow Fern | Faculty of Pharmacy, Universiti Kebangsaan Malaysia
  2. Dr. Saiful Effendi Syafruddin | UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia
  3. Dr. Fu Ju Yen | Malaysian Palm Oil Board
  4. Dr. Low May Lee | Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Malaysia
  5. Dr. Ahmad Hazri Abd Rashid | SIRIM, Malaysia
  6. Mr. Mohd Helme bin Mohd Helan | National Nanotchnology Center (NNC), Ministry of Energy, Science, Technology, Environment & Climate Change (MESTECC), Malaysia


  1. Prof. Dr. Maria J. Vicent | Polymer Therapeutics Laboratory, Centro de Investigación Príncipe Felipe, Spain
  2. Prof. Dr. Toyoko Imae | Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taiwan
  3. Prof. Dr. Dr. Nina Japundžić-Žigon | Institute of Pharmacology, Clinical Pharmacology and Toxicology, University of Belgrade. Serbia
  4. Prof. Dr. Kevin Burgess | Department of Chemistry, Texas A&M University. USA
  5. Prof. Dr. David Murphy | School of Clinical Sciences, University of Bristol, UK
  6. Prof. Dr. Edward James Johns | Physiology Department, University College Cork, Ireland
  7. Prof. Dr. Chia-Ching Chang | Department of Biological Science and Technology,National Chiao Tung University, Taiwan
  8. Prof. Dr. Dar-Bin Shieh | School of Dentistry, National Cheng Kung University, Taiwan
  9. Prof. Dr. Steve Roffler | Institute of Biomedical Sciences, Academia Sinica. Taiwan
  10. Prof. Dr. Shinru Shih | Research Center for Emerging Viral Infections, Chang Gung University, Taiwan
  11. Asst. Prof. Dr. Fabienne Dumoulin | Chemistry Department, Gebze Technical University. Turkey
  12. Prof. Khuloud Al-Jamal | Institute of Pharmaceutical Science, King’s College London, UK
Activities / Projects
(Completed/ ongoing/ prospective projects)


  1. Nano-stealthing the STAT3-blocker for improved anti-metastatic activity: mechanistic and pharmacological studies, FRGS 2017
  2. Targeted delivery of cancer chemotherapy pro-drugs, MOHE-HIR 2013
  3. Targeted delivery of anti-neoplastic photoactive compounds and peptides, MOHE-HIR 2011


  1. Fundamental Investigation on the Nanocarrier-assisted Rapid Drug Urothelial Mucopenetration and Ultrasound-regulated Tumour-selective Bladder Drug Delivery to Improve Intravesical Bladder Cancer Therapy, FRGS 2022
  2. Evaluating directed encapsulation of CRISPR/Cas9 as self-assembled ribonucleoprotein (RNP) complex into exosomes for CD73 ablation as locally administered lung cancer immunotherapy, FRGS 2022
  3. Development of industrial prototype of polymeric targeted and non-targeted nanoparticle formulation for the treatment of cancer: preclinical and technical evaluation, PRGS 2021
  4. Discovery of Novel Exosome-based Biomarkers for Machine-learning Assisted Biosensing in Lung Cancer Early Detection, IIRG 2021
  5. Targeting Tropomyosin Receptor Kinase C Expressing Cancer Cells through Synthetic Ligand Conjugate and Cyclophosphamide for Immunotherapy, FRGS 2020
  6. Bacterial membrane targeting agent - ruthenium/rhenium-based photosensitizer conjugates as novel effective therapeutics against multi-drug resistant bacteria: feasibility and synergistic mechanism studies, FRGS 2020
  7. Design And Development of Antimicrobial Molecules/anti-virulence Agents for Suppression of Biofilm Formation of Staphylococcus Aureus, IIRG 2019
  8. Stimuli responsive double-stealth–pre-targeting strategy to improve targeted anticancer nano-drug delivery to deep tumour tissues: Mechanism and pharmacology, FRGS 2019
Calls for

Expertise/ collaboration:

  1. Renal-targeted drug delivery
  2. Stimulus-guided nano-drug targeting/activation
  3. Nanotoxicity assessment
  4. Synthesis of low-dimensional nanotherapeutics
  5. Biosensor-based rapid drug-screening/medical diagnosis
  6. Exosome-based Nanobiologics
  7. Other nano-drug-delivery/ nanotherapeutics applications
Contact Us

Assoc. Prof. Dr. Kiew Lik Voon
Department of Pharmacology

Last Update: 23/02/2023