RIG - Tissue Engineering Group (TEG)

Regenerative Medicine, Tissue Engineering, Molecular Biology, Medical Biotechnology, Orthopaedics Biology, regenerative pharmacology

National 

1. Assoc. Prof. Dr Ardiyansyah Syahrom
2. Dr Chiu Chee Kidd
3. Assoc. Prof. Dr Lakshmi Selvatnam
4. Dr Norazian Kamisan
5. Dr Daniel Looi Qi Hao

International 

1. Prof. Dr. Li Gang Dr
2. Margaret M. Roebuck
3. Dr Hanumantha Rao Balaji Raghavendran
4. Assoc. Prof. Dr Belinda Murphy
5. Prof. Dr Golam Hossain

Activities

1. Preparatory Courses for Orthopaedics Specialty Committee (OSC) Part 1 Examination
2. Fundamental Cell Culture Workshop 2022
3. Histology Workshop
4. Literature Review: Conducting Literature Search and Writing A good Review
5. Scientific Writing and Getting Published: Knowing How and Where to Publish and the Alternative to thesis Submission
6. Training on sterile principles and gowning technique by KMTECH Malaysia
7. International Orthopaedic Postgraduate Symposium 2022
8. Osteoarthritis Symposium - Upcoming
9. Lab Induction for Atomic Force Microscope - Upcoming
10. Microarray workshop - Upcoming
11. Western Blot Workhsop - Upcoming

Projects (New projects)

1. The effects of Tumor Necrosis Factor activated NF-kappaB pathway attenuation by silencing RNF216/TRIAD3- E3 ligase in macrophage anti-inflammatory phenotypic commitments as a potential treatment for inflammation in arthritis
2. Uncover the potential role of silenced – ACSL4 and -LPCAT3 in induced-ferroptosis-chondrocytes in obese patients with osteoarthritis
3. A study investigating pro-inflammatory macrophage polarisation through leptin stimulated JAK2 pathway to delay osteoarthritis in high-fat diet induced obese C57BL/6J mice model.
4. The Clinical Application of a Novel Poly(Vinyl Alcohol)/N,O-Carboxymethyl Chitosan Scaffold Seeded with Bone Marrow Derived Mesenchymal Stem Cells for The Treatment Of Damaged Cartilage : A Phase I & II Clinical Trials For Future Commercialisation Purposes
5. Investigating the role of peripheral blood miRNAsas potential diagnostic, prognostic, and therapeutictargets in treating osteoarthritis
6. A study investigating biomechanical andchondrogenic induction features of poly (EthyleneGlycol)-chitosan scaffold incorporated with mesenchymal stromal cells to regeneratedamaged annulus fibrosus of herniatedintervertebral disc in rabbit model
7. An in vitro study to determine the role of mesenchymal stromal cells-laden antimicrobial organic-inorganic hybrid nanofibrous scaffolds for bone tissue engineering

Projects (On going projects)

1. Investigating The Role Of Hypoxia-inducible Factor Prolyl- And Asparaginyl-hydroxylases On Osteogenic Differentiation Of Human Adipose-derived Mesenchymal Stromal Cells
2. The clinical application of human amniotic membrane as a cell delivery vehicle in cellular therapeutic approach for treating damaged cartilage: Pre-clinical and Phase I human clinical trials
3. Clinical development of autologous platelet-derived extracellular vesicles (PEV) combined with peripheral blood-derived mesenchymal stem cells (PB-MSC) as a prototype for the treatment of osteoarthritis: Clinical trials involving Phase I and Phase II
4. A Study Investigating The Role Of Human Amniotic Membrane As A Carrier For Platelet Rich Plasma And Mesenchymal Stromal Cells To Promote Wound Healing In Acute Large Wounds: In Vitro And In Vivo Study
5. A Study Of Cd14+ Monocyte Migration And Osteoclast Maturation Responding To Stimuli From Human Revision Xenograft Transplanted In Nod-scid Mice Model
6. A Study Investigating The Role Of Infrapatellar Fat Pad Of Obese Patients In Activating Synovial Fibroblasts And Osteoarthritis Progression By Promoting Catabolic Response From Chondrocytes
7. Investigating The Effects Of Moderate Physical Exercise On Cartilage Degeneration And Early Subchondral Bone Remodelling At The Tibial Plateau Of Anterior Cruciate Ligament Transected Osteoarthritis Rat Models
8. A Multi-modality Investigation On The Prediction Of Early Diagnosis Of Oa With The Integration Of Deep Learning And Molecular Metabolic Profiles Approach
9. A Study Investigating the Role of Mesenchymal Stromal Cell Derived Secretome in Reprogramming Pro-Inflammatory Macrophages into Anti-Inflammatory Phenotype

Expertise/ collaboration: 

We welcome all collaberators in above fields

Vacancies:

Ph.D.: currently 3 positions are avalable

Prof. Dr. Alimohammad Sharifi
Department of Orthopaedic Surgery
https://umexpert.um.edu.my/alisharifi.html  
03-79672693
alisharifi@um.edu.my