Renal Pharmacology And Drug Targeting

Contact Person

Prof Dr. Nor Azizan Abdullah (azizan@ummc.edu.my)

Dr. Kiew Lik Voon (lvkiew@ummc.edu.my

Introduction

  1. Discovery and development of drugs for the amelioration of diabetic nephropathy

Diabetic nephropathy is a major cause of kidney failure worldwide; a problem that is a huge burden to the healthcare system and costly to those living with it. Understanding its pathogenesis and finding the appropriate bioactive compounds to stop the progression of this disease is vital.

  1. The pharmacogenomics of diabetes mellitus and diabetic nephropathy

Diabetes mellitus and its associate complications are on the rise worldwide. Many studies indicated that energy-rich diet with lack of physical exertion to be the main culprit. However, there are studies that have shown the propensity for diabetes mellitus and diabetic nephropathy development in family clusters, indicating an inheritance component. We are examining a segment of the Malaysian population to investigate the relationship between selected single nucleotide polymorphisms and the incidence of diabetes mellitus as well as diabetic nephropathy.

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